When must the prescription be signed by the prescribing practitioner?

The correct answer is that the prescription must be signed by the prescribing practitioner on the day when it is issued. This requirement ensures that the prescription is valid and reflects the practitioner's current judgment regarding the patient’s needs. Signing the prescription on the same day of issuance helps prevent misuse or alterations that could occur after the fact. It also aligns with legal and regulatory standards to ensure patient safety and proper record-keeping.

The other options do not meet the legal requirements for prescription validation. Signing at the end of treatment or upon patient request does not guarantee that the prescription reflects the current medical necessity at the time it is needed. Similarly, signing within 30 days of issuance creates ambiguity and potential issues regarding the validity and intent of the prescription, as medical needs may change over time. Therefore, signing on the day of issuance is essential for maintaining the integrity of the prescribing process.